CardioLab, Version 3.0

BIOSOFT (Acropolis Computers Ltd) stopped selling its software programs on 31st December 2022.

Messages sent to info@biosoft.com requesting program activation passwords and basic technical support will continue to be answered for 2 years from the above date.

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CardioLab Version 3.0 simulates in vivo cardiovascular pharmacology experiments. CardioLab costs less than a single dog or cat and can be used repeatedly to simulate chart recorder outputs of experiments on anaesthetised (normal or reserpinised) animals and pithed animals. The simulated heart rate and blood pressure traces appear on screen and can be printed out. CardioLab allows administration of the following 10 drugs of Agonists: Norepinephrine (Noradrenaline); Angiotensin; Vasopressin; DMPP; Epinephrine (Adrenaline); Tyramine; Phenylephrine; B-HT 920; Isoproterenol (Isoprenaline) and Acetylcholine. In addition it allows administration of the following 12 drugs of Antagonists: Hexamethonium; Propranolol; Prazosin; Atropine; Mepyramine; Ranitidine; Yohimbine; Atenolol; Nifedipine; Phenoxybenzamine; Cocaine and Neostigmine. CardioLab can also mimic stimulation of vagal and sympathetic cardiac nerves. The effects of blockers (antagonists) "wear off" at a rate corresponding to their t1/2. Overdoses with agonists or blockers will "kill" the preparation. Responses are subject to "biological variation" and are influenced by cardiac compensatory reflexes if appropriate. Tachyphylaxis is seen with relevant agonists. CardioLab even simulates the slow deterioration of a preparation which may "die" unexpectedly after six hours of "preparation time" (responses appear instantaneously but represent about 3 minutes of "preparation time"). CardioLab can provide "unknown" drugs for characterisation by students.

A screenshot and a downloadable demo is available here. This program can be ordered online. Includes user manual as pdf. This item may be borrowed for up to 6 weeks through the Alternative Loan System of the International Network for Humane Education (InterNICHE), free of charge, but return postage must be paid by the person who has borrowed the product. Please note that there are practical limitations on where some items can be sent. Please contact loansystem@interniche.org and see http://www.interniche.org for more information. Orders outside the United Kingdom, please click here.

Price: Single user license: US$135/£75; 5 user licence: US$440/£225; 10 user licence: US$675/£375 (all include a manual as pdf file); An additional charge of US$35/£20 is made for supply of a hard copy (CD) if required.

Version: Version 3.0