The Mouse in Biomedical Research: Immunology, Volume 4, Second Edition

This book is a completely new addition to this series and present an overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. It is based on the vast knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.  

Table of Contents: Molecular and Cellular Immunology of the Mouse: An Overview: 1 The Molecular Basis of Lymphoid Architecture in the Mouse; 2 The Biology of Toll-like Receptors in Mice; 3 Genomic Organization of the Mouse Major Histocompatibility Complex; 4 Some Biological Features of Dendritic Cells in the Mouse; 5 Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes; 6 Mouse Natural Killer Cells: Function and Activation; 7 Cytokine-activated JAK-STAT Signaling in the Mouse Immune System; 8 Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse; 9 Mouse Models of Negative Selection; 10 Peripheral Tolerance of T Cells in the Mouse; 11 The Genetics of Mouse Models of Systemic Lupus; 12 Inhibitory Receptors and Autoimmunity in the Mouse; 13 Mouse Models of Immunodeficiency; 14 Mouse Models to Study the Pathogenesis of Allergic Asthma; 15 The Mouse Trap: How Well Do Mice Model Human Immunology? 

Second Edition. 392 pages. Available as a Hardback + eBook, Hardback only and as an eBook only. This title is the fourth (Volume 4) in a series of four volumes with comprehensive coverage of all aspects of mouse biology and breeding. This textbook is sponsored by  the American College of Laboratory Animal Medicine (ACLAM). Please see record numbers 6053, 6054 and 6057 for Volumes 2, 3 and 1 in this series. All four books in this series are also available as One Volume (2192 pages, ISBN: 0-12-369454-X, 2006). Published by Academic Press, now part of Elsevier.

ISBN-13: Hardback: 9780123694584; eBook: 9780080469089

Price: Hardback + eBook: $150.50; Hardback only: $108.50; eBook only: $102.20