ARRIVE Guidelines

The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines were developed to improve standards of reporting the results of animal experiments. The guidelines are primarily aimed at scientists writing up their research for publication and for those who are involved in peer review.

The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines were developed to improve standards of reporting the results of animal experiments. The PREPARE guidelines for planning animal research and testing provide guidelines for planning animal research from day one.

The latest version of the ARRIVE guidelines (ARRIVE 2.0, published in July 2020) consists of two checklists: the Essential 10 (the basic minimum of information to include in a manuscript) and the Recommended set (topics which add context to the study described).

The PREPARE guidelines have a similar multi-language checklist for use when planning experiments, with comprehensive webpages containing links to international resources for each topic on the checklist.

A comparison between PREPARE and ARRIVE can be read here and a 3-minute cartoon film illustrating the complementary role of planning and reporting guidelines can be accessed here.

The new version of ARRIVE does not mention the 3R concept (Replacement, Reduction, Refinement) specifically. Norecopa recommends a 3-step approach for scientists conducting animal studies:

  1. Use the PREPARE guidelines from day 1 of planning, to implement the 3Rs and identify all the factors which can affect the validity of their research
  2. Use reporting guidelines like ARRIVE, the Gold Standard Publication Checklist or other other reporting guidelines to write a manuscript which has the best chances of being accepted by a journal
  3. Make sure that any advances in the 3Rs which were made during the study are prominently mentioned in the manuscript, preferably in the title and/or abstract, since many databases only index these parts of a paper.


References

 

This page was updated on 25 September 2020

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