Applied In Vitro Toxicology Course (1) (Applied In Vitro Toxicology Course)
Owner/Developer: The European Society of Toxicology In Vitro and the American Society for Cellular and Computational Toxicology (ESTIV, ASCCT)
14 April 2019
This 6-day course is organized by ESTIV in collaboration with the ASCCT and combines cutting-edge lectures by leading experts with highly interactive group exercises.
In vitro toxicity methods are gaining importance, in particular as a response to a number of European legislative changes that call for more mechanistically-based decision-making and limit or even prohibit the use of animal experimentation for risk assessment purposes. Hence, there is an urgent demand for toxicologists and risk assessors to implement in vitro testing results into regulatory safety evaluation of chemicals. This course aims at meeting this ubiquitous need by training individuals who wish to start or pursue a career in this direction or to gain an update on the state-of-the-art of applied in vitro toxicology.
Hands-on training, Lecture
Optional / Voluntary
Applicants should ideally have a background in toxicology, biology, chemistry, (bio)medical sciences, pharmaceutical sciences, veterinary sciences or equivalent. Attendees are expected to be proficient in English. A maximum of 30 participants will be enrolled in the course on a first-pay/first-served basis, yet priority will be given to members of ESTIV, ASCCT and affiliated societies. The number of participants originating from and based in Romania is limited to 10.
Regulators and policy-makers, Researchers, Students
Governmental bodies, Industry, Academia
Continuing Professional Development
In vitro methods, Legislative aspects
Full coverage (a dedicated course)
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The course consists of a series of lectures and hands-on exercises on skin and eye irritation. It is taught by experts in three areas of in vitro toxicology, namely regulatory in vitro toxicology, screening in vitro toxicology and investigative in vitro toxicology.
European legislative framework and international guidelines for in vitro toxicity testing of chemicals.
Use and validation of 3R-alternative methods in Europe and the USA.
In vitro methods for assessing cytotoxicity, skin sensitization, skin/eye irritation/corrosion, immunotoxicity, genotoxicity, carcinogenicity and reproductive toxicity.
Development and application of cell lines, organ-specific models, tridimensional and reconstructed models, bioreactors and stem cell models in in vitro toxicology.
Use of “omics”-based methods in in vitro toxicology.
Good cell culture practice.
In vitro kinetics and in vitro–in vivo extrapolation.
In vitro aspects of pathway-based toxicology.
Non-animal testing technologies and strategies used for chemical hazard and risk assessment in Europe and the USA.
Hands-on training on skin and eye irritation testing in vitro.
The lectures cover a broad spectrum of subjects pertinent to regulatory, screening and investigative in vitro toxicology. The group exercises consist of real-life case studies in which the participants will apply the principles of in vitro toxicology to the risk assessment of chemical substances.
Course examination will be based upon presentation and discussion of the case studies. Furthermore, the participants will be given the opportunity to gain hands-on experience with respect to skin and eye irritation testing in vitro.
The participants will receive a certificate in case of a positive evaluation.
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