Mechanisms of action (MechoAs): In what way is your substance toxic?
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Owner/Developer: Chemical Watch (CW)
To predict the toxicity of substances using Read-Across or (Q)SAR models with confidence and reliability, the Mechanism of Action (MechoA) of substances, i.e. the molecular mechanism by which they exert their toxicity, must be identified.
In the field of ecotoxicology, several classification methods to predict the Mode of Action (MoA) of substances exist, however, MoAs are generally not clearly defined. At KREATiS, we have developed a universal method of classification of MechoAs for use in both fields.
MechoAs are a useful tool for hazard assessment to strengthen mechanistic interpretation, read-across justification and weight of evidence and QSAR approaches.
The webinar will introduce the newly launched iSafeRat® Online platform, where MechoA predictions can be accessed for free.
Optional / Voluntary
High school, Technical College, Undergraduate, University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development
Full coverage (a dedicated course)
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Predict the toxicity of substances using Read-Across or (Q)SAR models with confidence and reliability, the Mechanism of Action (MechoA) of substances, i.e. the molecular mechanism by which they exert their toxicity, must be identified.
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