NEVR8014 -Laboratory Animal Science for Researchers
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Owner/Developer: Norwegian University of Science and Technology (NTNU)
The course follows the requirements in the Norwegian regulation on animal experimentation (FOR-2015-06-18-761) §25 and annex E. Additionally, the course aims to follow the Education and Training Framework by the European Commission to fulfill the requirements for functions (a) (persons who carry out procedures on animals) and (b) (persons who design procedures and projects).
The course does not cover practical training. After completion of this course you will most likely be able to bring your diploma to other European countries and work with research animals. Please note that other countries might ask for additional training and have different national requirements.
Interactive online resources, Lecture
Recommended previous knowledge
Basic knowledge in anatomy and physiology, competence in statistics, knowledge about literature searches on the internet and in libraries
Required previous knowledge
A 3-year education at university or college level is a prerequisite in order for the participant to plan and design procedures and projects (Function (b) in the EU Directive 2010/63).
Enrolment in a PhD programme, master programme or at "forskerlinjen" in medicine at NTNU. PhD- and "forskerlinje"-students at the Medical faculties at UiT, UiB and UiO are given access according to a mutual agreement between these universities. Others interested in this course are referred to the course MDV6003; Laboratory Animal Science for Researchers
University (Master), University (Doctoral education), Postdoctoral (teaching and research)
Refinement, Reduction, Replacement
Killing animals, Carrying out procedures on animals, Taking care of animals, Computational methods, Ethics, Legislative aspects
Substantial coverage (e.g. multiple modules)
Rodents, Pigs (Sus scrofa domesticus), Other Fish (other Pisces)
|Course level on animal species:||
|Details on the topic or technology covered:||
The course will cover the following topics:
- Ethics, animal welfare, and 3R;
- Different views in the society;
- Species specific biology of laboratory animals;
- Management of laboratory animals;
- Microbiological qualities;
- Genetically modified animal models;
- Environmental factors that may influence animal experiments;
- Health hazards;
- Assessment of pain and humane endpoints;
- Severity classification;
- Humane killing of animals,
- Public administration and the course of events in animal experiments;
- Design and statistics;
- Principles of minimally invasive procedures on animals;
- Anesthesia and analgesia for minor and long-lasting procedures;
- Basic surgery
Directive 2010/63/EU or equivalent, Other
- Identify and describe the national and European legislation which regulate the scientific use of animals
- Describe the authorisation that is needed before acting as a user, breeder or supplier of laboratory animals and especially the authorisation required for projects
- Indicate who bears primary responsibility for the animals undergoing procedures
- Describe the differing views within society concerning the scientific use of animals
- Identify ethical and animal welfare issues in their own work
- Demonstrate a comprehensive understanding of the principle of the 3Rs, list examples of how the 3Rs can be implemented in research projects and list sources of information related to the 3Rs
- Describe the severity classification system and give examples of each category
- Describe the basic biology of the relevant animal species, including basic anatomy, physiology, reproduction and behaviour; and recognise the importance of attending to biological and behavioural needs
- Describe the importance of providing an enriched environment to laboratory animals and give examples of environmental enrichment that is appropriate to the species
- Describe the environmental factors of importance for maintaining an appropriate health status for the animals, and how a laboratory animal facility is organized to maintain an appropriate health status and welfare of animals
- Describe the biological consequences of acclimatization, habituation and training
- Describe how genetically altered animals can be used for scientific research and the importance of monitoring such animals very carefully
- List potential human health hazards associated with contact with laboratory animals and describe how these can be prevented or reduced
- Describe abnormal behaviour and signs of discomfort, pain, suffering or distress
- Discuss methods available for assessing animal welfare
- Describe the principle of implementing early humane endpoints and how this implementation can influence animal health and welfare during the course of an experiment
- Define the term "humane killing" and list appropriate euthanasia methods for the relevant animal species
- Recognise that the choice of a euthanasia method may influence the scientific outcome
- Describe appropriate methods and principles for handling animals, and describe common techniques / procedures, including administration and sampling techniques
- Describe where to find relevant and up-to-date information about refinement of animal experiments
- List the different types of formal experimental designs
- Identify the experimental unit
- Describe the variables affecting significance, including the meaning of statistical power and the "p-value"
- Describe how to monitor the microbiological health of laboratory animals
- Describe the terms sedation, local anesthesia and general anesthesia
- Describe the components of pain physiology and list the types of analgesic drugs that are effective at the different components
- Define the term "Balanced anesthesia" and indicate methods to achieve this
- Describe how to do pre-operative, intraoperative and post-operative evaluation of research animals
- Describe different methods to optimize post anesthetic recovery
- Indicate some of the problems associated with pain recognition and pain management in animals
|Accreditation body and/or authority that approved the education or training:||
Diploma to work with research animals
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