Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis
|Disease mechanism (exp/theor)
|Not relevant (e.g. In silico)
The study authors combined in vitro studies with a multi-scale hybrid agent-based computational model that describes fibroblasts and epithelial cells in co-culture. Within this model TGF-β1 represents a pro-fibrotic mediator and we include detailed dynamics of TGF-β1 receptor ligand signaling in fibroblasts.
This in silico model captures the coregulation of fibroblasts and epithelial cells in vitro. There is substantial support for constructing agent-based models (ABMs) of in vitro co-culture systems. These models are used to study a wide range of processes including, but not limited to wound healing, tissue patterning, and tumor progression.
|Warsinske, Hayley C. - Wheaton, Amanda K. - Kim, Kevin K. - Linderman, Jennifer J. - Moore, Bethany B. - Kirschner, Denise E.
Did you find what you were looking for?Yes, I found it! No, I did not!
Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!Please contact us by email if you have any questions.