Chemical Assessment according to Legislation Enhancing the In silico DOcumentation and Safe use (Caleidos)
Owner/Developer: European Commission Environment - LIFE Programme (EC)
| Country: | Italy |
|---|---|
| Languages: | English |
| Url: | http://www.caleidos-life.eu/index.php |
| Contact: | http://www.caleidos-life.eu/pages/contacts.php |
| Contact Email: | info@caleidos-life.eu |
| Description: |
Main Objectives: to provide practical information to the users of non-testing methods (QSAR, read across and grouping), based on exercises done on the registered chemicals; to organise a statistically sound evaluation of the results in prediction of 23 quantitative structure-activity relationship (QSAR) methods, applying them to predict the properties of the chemicals registered to ECHA, and comparing the predicted values with the experimental ones in the registration data, for 6 properties: logP, bioconcentration factor, fish acute toxicity, mutagenicity (Ames test), carcinogenicity and reprotoxicity; to evaluate if read across and grouping methods can improve the predictions, comparing the results from these non-testing methods with those obtained with QSAR for a set of selected chemicals; to evaluate the reproducibility of the prediction using read across, organising an exercise with tens of experts; to make freely available a web tool for the prediction of six chemical properties (logP, bioconcentration factor, fish acute toxicity, mutagenicity (Ames test), carcinogenicity, reprotoxicity); to establish a network of tens of experts from regulatory bodies, industry and scientists, aiming to integrate the scientific and policy aspects; to improve standardisation on the use of non-testing methods. |
| Category: | Research Program/Project/Grant |
| Channel: | Website |
| Audience: | Scientists - Regulators - Industry - Researchers |
| User access: | Open access |
| Updating frequency: | 2015 |
| Relevance: | Replacement - Reduction |
| Purpose: | Toxicological and safety evaluation - Method development - Documentation and information - Education and training |
| Legislative framework: | REACH Regulation (EC) No 1907/2006 |
| Technology/Tools: | Non-testing methods (in silico) |
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