Integrated Testing Strategies (ITS) for Safety Assessment
Owner/Developer: Alternatives to Animal Experimentation (ALTEX)
Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.
|Channel:||Website - Printed|
|Audience:||Scientists - Regulators - Industry - Researchers|
|User access:||Open access|
|Updating frequency:||November 2014|
|Relevance:||Replacement - Reduction|
|Purpose:||Documentation and information|
|Technology/Tools:||Integrated approaches to testing and assessment (IATA)|
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