Blood sampling is one of the commonest procedures conducted on research animals, but it may cause pain, distress and lasting harm if the technique is poor, or if too much of the circulating blood volume is removed.
The following criteria are a good yardstick for judging the quality of a method for blood sampling:
- The blood vessel is visible
- The amount of blood that is removed can be controlled
- It is easy to stop the bleeding after the sample has been taken
- The surrounding tissue is not damaged
Not all methods for bleeding animals satisfy all these criteria.
The Norwegian University of Life Sciences (NMBU) has produced a range of videos and slide series showing handling, injection and blood sampling techniques on several laboratory animal species (hen, mink, mouse, pig, rabbit, rat).
- Procedures with Care (mice and rats)
- NC3Rs Microsite on blood sampling
- Bonnet, El Hassani, Lecq et al. (2016): Blood mixtures: impact of puncture site on blood parameters
- Hem, Smith & Solberg (1998): Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guineapig, ferret and mink
- Aasland, Skjerve & Smith (2010): Quality of blood samples from the saphenous vein compared with the tail vein during multiple blood sampling of mice
Did you find what you were looking for?Yes, I found it! No, I did not!
Thanks for your feedback! Please note that we cannot respond unless you supply your email address.
What are you looking for?
Please give us your feedback so we can improve the information on the page. Thank you in advance for your help. Please add your email address if you would like a reply.Please contact us by email if you have any questions.