Replacement of animals in research
Replacement is one of the "three Rs" (Replacement, Reduction and Replacement) of Russell and Burch, a concept which is described in more detail here.
They defined the three Rs as:
Replacement alternatives: methods which permit a given purpose to be achieved without conducting experiments or other scientific procedures on animals
Reduction alternatives: methods for obtaining comparable levels of information from the use of fewer animals in scientific procedures, or for obtaining more information from the same number of animals
Refinement alternatives: methods which alleviate or minimise potential pain, suffering or distress, and which enhance animal well-being
The PREPARE guidelines contain links to many resources which can be used to implement the 3Rs.
Please see this page for more information in alternatives to animals in research and testing.
The road to replacement (Genevieve Barr & Alice Carstairs, 2023)
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