Drug Safety Evaluation
By Jean-Charles Gautier (Ed.)
| Record number: | f675b |
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This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatisation of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs.
Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
23 chapters, including one on Procedures of Necropsy and Tissue Sampling (preview) and one on Tissue Sampling and Processing for Histopathology Examination (preview). Table of Contents.
ISBN: Softcover: 978-1-4939-8406-0, Hardcover: 978-1-4939-7170-1, eBook: 978-1-4939-7172-5
Softcover: € 149.99, Hardcover: € 149.99, eBook: € 117.69
Year: 2017
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