The Germ-Free Animal in Biomedical Research

Contents: List of contributors; Foreword; Explanation of terms; Introduction: The germ-free animal: its potential and its problems; SECTION 1: METHODOLOGY, Chapter 1: Equipment; Chapter 2: Production of germ-free animals, Part 1. Small mammals, Part 2. Farm animals, Part 3. Birds; Chapter 3: Diets for germ-free animals, Part 1. Sterilization of diets, Part 2. The germ-free animal fed chemically defined ultrafiltered diets; Chapter 4: Microbiological monitoring of gnotobiotic isolators; SECTION 2: MICROBIAL ECOLOGY, Chapter 5: Present view of the normal flora; Chapter 6: Microbial interactions in the digestive tract; Chapter 7: Colonization resistance of the digestive tract; SECTION 3: PHYSIOLOGY, Chapter 8: Physiology of the alimentary tract; Chapter 9: Anomalous lower bowel function and related phenomena in germ-free animals; Chapter 10: Other organs; SECTION 4: NUTRITION AND METABOLISM, Chapter 11: Nitrogen metabolism; Chapter 12: Carbohydrate metabolism; Chapter 13: Vitamins; Chapter 14: Mineral metabolism; Chapter 15: Fatty acids; Chapter 16: Metabolism of bile acids; Chapter 17: Metabolism of cholesterol; SECTION 5: IMMUNOLOGY, Chapter 18: Influence of the microflora on the immune response, Partr 1. General characteristics of the germ-free animal, Part 2. Gnotobiotic animals in immunological research; SECTION 6: APPLICATION OF GNOTOBIOTIC ANIMALS IN MEDICAL RESEARCH, Chapter 19: The germ-free animal as a tool in cancer research; Chapter 20: Gnotobiotic rats in studies of drug metabolism; Chapter 21: Radiation pathology and treatment.

Laboratory Animal Handbook Series, No. 9. 289 pages. Hardback. The Laboratory Animal Handbooks are published by Royal Society of Medicine Press (RSM), for Laboratory Animals Ltd in London. Out-of-print. This book is no longer available from RSM. Please try Amazon.

ISBN: 978-0-901334-10-7