| DOI: | https://doi.org/10.1172/jci.insight.91377 |
|---|---|
| Reference: |
3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs |
| Disease Area: | Pulmonary Fibrosis |
| Type: | See notes |
| Application: | Mimics lung microenvironment |
| Biological Endpoints: | Cytokine Release |
| Throughput: | Medium / Low (Lab scale) |
| Potential: | Drug Development |
| Notes: |
This ex vivo 3D model uses lung tissue from patients to develop pulmospheres. Pulmospheres are 3D spheroids composed of cells derived exclusively from primary lung biopsies and inclusive of lung cell types reflective of those in situ, in the patient. |
| Authors: | Surolia, Ranu - Li, Fu Jun - Wang, Zheng - Li, Huashi - Liu, Gang - Zhou, Yong - Luckhardt, Tracy - Bae, Sejong - Liu, Rui-ming - Rangarajan, Sunad - de Andrade, Joao - Thannickal, Victor J. - Antony, Veena B. |
| Year: | 2017 |
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