Zebrafish

Zebrafish (Danio rerio) are being used in increasing numbers within molecular biology, developmental biology, neurobiology, genetics, cancer research and drug discovery, due to the low costs of maintaining them, their short generation interval, the transparency of the embryos and the ability to manipulate the genome.

Norecopa's secretary gave a presentation entitled 3Rs Resources and Guidelines for Zebrafish at the NC3Rs/Cefas workshop on Addressing the needs for refinement of laboratory fish in Weymouth, 26-28 April 2016. This presentation includes:

  • international guidelines for the care and use of zebrafish
  • organisations and journals related to zebrafish research
  • suggestions on how to improve literature searches and reporting

A shorter version, just containing the 3R resources and guidelines, is available here.

The Research Animals Department of the RSPCA has produced a guidance document on the care and housing of zebrafish.

Dr. Lynne Sneddon, Liverpool University, held a presentation at Norecopa's annual general meeting entitled Detection and alleviation of pain in fish, which mentions zebrafish.

International survey on the use and welfare of zebrafish Danio rerio in research (Journal of Fish Biology, February 2017)

Selected references on anaesthesia and analgesia of zebrafish


Zebrafish anatomy portal 

Other literature and media articles

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