Omics in mechanistic and predictive toxicology.
Owner/Developer: Toxicology Mechanisms and Methods
Country: | United Kingdom |
---|---|
Languages: | English |
Url: | http://www.tandfonline.com/doi/abs/10.3109/15376510903559976?journalCode=itxm20 |
Description: |
High-throughput omics strategies delineate the molecular mechanism of toxicity, predict the toxicity of newer drugs and chemicals, and identify individuals at high risks on the basis of expression patterns of messenger ribonucleic acids, genes, and proteins, and detection of intermediary metabolites. Despite being a developing country, India is one of the fastest growing nations in the usages and applications of omics technologies. Several differentially expressed genes and proteins under various pathological and toxicant-exposed conditions have been identified, and many association studies on genetic polymorphisms with toxicant-induced diseases have been conducted for the predictive and mechanistic purposes. To date, omics-driven approaches have identified some novel fingerprints associated with disease risk/protection and prediction of toxicity of newer chemicals. Although the contributions of such findings in the mechanistic toxicology have been immense, predictive values of these findings in toxicology have been limited. In this review, the current status of omics-based research and its future possibilities at the Indian Institute of Toxicology Research (IITR), Lucknow, India, have been discussed. |
Category: | Publication |
Channel: | Website |
Audience: | Students - Scientists - Industry - Researchers - Regulators |
User access: | User registration - Fee-based access |
Updating frequency: | 2010 |
Relevance: | Replacement - Reduction |
Purpose: | Documentation and information |
Technology/Tools: | Omics |
Did you find what you were looking for?
Yes, I found it! No, I did not!Thanks for your feedback! Please note that we cannot respond unless you supply your email address.
What are you looking for?
Please give us your feedback so we can improve the information on the page. Thank you in advance for your help. Please add your email address if you would like a reply.
Please contact us by email if you have any questions.