Systematic Review Centre for Laboratory animal Experimentation (SYRCLE)
Owner/Developer: Radboud University Medical Center
SYRCLE was the research and education centre of the Central Animal Laboratory (CDL) of the Radboud University Medical Center. Systematic Review (SR) is the methodological approach SYRCLE has adopted for the Syntheses of Evidence (SE). SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation) was officially founded in 2012. Already in 2008/2009 the research staff had shifted their focus from the 3Rs towards the execution of systematic reviews (SR), because these are a method to identify, appraise, select and synthesise all available research results. SRs help to improve scientific quality, facilitate the implementation of the 3Rs and –last but not least- aid in securing patient safety. SYRCLE focused on the execution of SRs of animal studies towards more evidence-based translational medicine. To this effect SYRCLE developed education, methodological tools and guidelines, organizes workshops and coached individuals wishing to perform a SR themselves.
SYRCLE has now been disbanded but their work is being carried on by the Meta-Research Team at Radboud University Medical Center.
|Scientists - Researchers
|Replacement - Reduction - Refinement
|Animal welfare - Education and training - Documentation and information
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