Test Method Evaluation Report on In Vitro Ocular Test Methods
Owner/Developer: US Department of Health and Human Services, National Toxicology Program (NTP)
|United States of America
In August 2003, the ICCVAM Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) recommended that ICCVAM give high priority to reviewing the validation status of existing in vitro test methods proposed for identifying ocular corrosives and severe irritants. In October 2003, the US Environmental Protection Agency (EPA) formally nominated four in vitro ocular irritation test methods and related activities for evaluation by ICCVAM. This included review of the current validation status of four in vitro test methods proposed for identifying potential ocular corrosives and severe irritants in a tiered-testing strategy, since validation5 of a test method is a prerequisite for it to be
considered for regulatory acceptance (ICCVAM 1997, 2003).
|Scientists - Regulators - Industry
|Replacement - Reduction
|Documentation and information
|Alternative test methods (in vitro)
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