Using computational models to predict fish acute toxicity of pesticide metabolites
Owner/Developer: National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs)
An analysis, published recently in Regulatory Toxicology and Pharmacology, has shown that Quantitative Structure–Activity Relationship (QSAR) models could potentially be used to predict whether plant protection product (PPP) metabolites are acutely toxic to fish. The work was led by the NC3Rs, in partnership with scientists from Dow AgroSciences, Syngenta and BASF.
|Audience:||Scientists - Regulators - Industry|
|User access:||Open access|
|Updating frequency:||13 July 2016|
|Relevance:||Replacement - Reduction|
|Purpose:||Toxicological and safety evaluation - Documentation and information|
|Technology/Tools:||Non-testing methods (in silico)|
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