Historical Control Data for Development and Reproductive Toxicity Studies using the Crl:CD BR Rat

This project is a continuation of MARTA's (Middle Atlantic Reproduction and Teratology Association) efforts to collect and summarize historical control data from developmental and reproductive toxicology studies conducted at laboratories of member companies. Previous MARTA efforts include projects concluded in 1979 (Sprague-Dawley rat reproduction), 1982 (New Zealand White rabbit reproduction), 1990 (CD* rat and New Zealand White rabbit reproduction), and 1991 (external anomalies in CD* rats). The first two projects were published as abstracts (Woo and Hoar, 1976, 1982), while the latter two projects were distributed in mailings to the MARTA membership. The present project collected data on reproduction, visceral, and skeletal anomalies in the CD* rat. The previously collected data on external anomalies is included here for completeness. There have been very few other comprehensive compilations of these type of data in the open literature. A list of available references for rodents and rabbits is provided in this document.

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