Alternatives to the use of fish in research
This page is being used to gather links to 3R-alternatives to the use of fish in research.
- The Centre for Digital Life at the Norwegian University of Science and Technology NTNU coordinates several projects including construction of a salmon simulator and a digital brain, to reduce the use of live animals in neurological research (Laksesimulator og digital hjerne i nytt forskningssenter)
- The Microtox Test System, which is based upon the use of luminescent bacteria, specifically the strain Vibrio fischeri, to measure toxicity from environmental samples.
- Goksøyr A (2005) Alternative techniques in fish toxicity testing. A presentation at an international consensus meeting on the care and use of fish in research.
- ALTBIB Bibliography on Alternatives to Animal testing. A search on "Fish" provides plenty of papers on fish models as alternatives to mammalian models, but very few models to replece the use of live fish.
- The Use of Fish Cells in Ecotoxicology: a report from an ECVAM workshop into the potentials for replacing the use of live fish.
- Defoirdt T, Bossier P, Sorgeloos P, Verstraete W (2005) The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana. Environ Microbiol 7: 1239-1247. A bioassay for the use of artemia instead of live fish.
Ellis T, James JD, Stewart C, Scott AP (2004) A noninvasive stress assay based upon measurement of free cortisol released into the water by rainbow trout. Journal of Fish Biology 65, 1233-1252.
Turner et al 2003, Measurement of fecal glucocorticoids in parrotfishes to assess stress.
Scott AP, Pinillos M, and Ellis T (2001): Why measure steroids in fish plasma when you can measure them in the water? In: Perspectives in Comparative Endocrinology (Goos T, Rastogi RK, Vaudry H & Pierantoni R, eds). Bologna: Monduzzi Editore, 1291-1295.
Segner H (1998) Fish cell lines as a tool in aquatic toxicology Exs 86:1-38
Balls M, Bridges J & Southee J (1991): Animals and Alternatives in Toxicology. London: Macmillan Press. Methods for replacing fish with the water flea (Daphnia magna).
The NORINA database contains information on over 3500 audiovisual aids that may be used as alternatives or supplements to the use of animals in teaching. A search on fish provides alternatives within areas such as anatomy and physiology.
The TextBase database contains information on over 1500 books on topics related to laboratory animal science and alternatives. A search on fish provides useful information on topics related to the care and use of fish in research.
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