Steps should be taken to avoid surplus animals, such as those in breeding programmes which prove to be too old, those which respond poorly to treatment (for example by showing a weak immune response) or which are otherwise unsuitable for re-use, re-homing or release.
Resources
- Reducing surplus experimental animal generation - a report from GV-SOLAS (2022)
- Breeding and colony management - Frequently Asked Questions (NC3Rs webpage)
- Hart-Johnson & Mankelow (2021): Archiving genetically altered animals: a review of cryopreservation and recovery methods for genome edited animals
- Grannec & Nosten-Bertrand (2018): Optimal breeding strategy for mouse mutant strains
- Moreno-del Val & Munos-Robledano (2019): Cryopreservation of genetically modified mouse strains: preserving valuable material, saving resources and reducing animal usage
- aRukon - a cloud-based global system for sharing animal tissue
- UK Government advice on non-human primates used for scientific purposes
- The European Mutant Mouse Archive (EMMA) from INFRAFRONTIER
- Does your disaster mitigation strategy include rederivation? (paper from Envigo)