Relationship between PREPARE and ARRIVE

The PREPARE guidelines for planning animal experiments are complementary to reporting guidelines such as ARRIVE. They should be used in conjunction, to ensure that important topics have not been omitted. PREPARE includes topics which are not necessary to report in a scientific paper, but which can seriously affect the scientific quality of an animal study (as well as causing health risks to both humans and animals) if they are not addressed satisfactorily.

This table compares the 15 points in the PREPARE guidelines checklist with the 20 points in the ARRIVE guidelines.

PREPARE:

Formulation of the study

1.     Literature searches

2.     Legal issues

3.     Ethical issues, Harm-Benefit Assessment and humane endpoints

4.     Experimental design and statistical analysis

Dialogue between scientists and the animal facility

5.     Objectives and timescale, funding and division of labour

6.     Facility evaluation

7.     Education and training

8.     Health risks, waste disposal and decontamination

Quality control of the components in the study

9.     Test substances and procedures

10.  Experimental animals

11.  Quarantine and health monitoring

12.  Housing and husbandry

13.  Experimental procedures

14.  Humane killing, release, re-use or re-homing

15.  Necropsy

ARRIVE:

1.     Title

2.     Abstract

Introduction

3.     Background

4.     Objectives

Methods

5.     Ethical statement

6.     Study design

7.     Experimental procedures

8.     Experimental animals

9.     Housing and husbandry

10.  Sample size

11.  Allocating animals to experimental groups

12.  Experimental outcomes

13.  Statistical methods

Results

14.  Baseline data

15.  Numbers analysed

16.  Outcomes and estimation

17.  Adverse events

Discussion

18.  Interpretation/scientific implications

19.  Generalisability/translation

20.  Funding

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