Relationship between PREPARE and ARRIVE

The PREPARE guidelines for planning animal experiments are complementary to reporting guidelines such as ARRIVE. They should both be used, to ensure that important topics have not been omitted.
We have tried to illustrate this in a cartoon film.

Here is a 3-step approach for scientists conducting animal studies:

  1. Use the PREPARE guidelines from day 1 of planning, to implement the 3Rs and identify all the factors which can affect the validity of their research
  2. Use reporting guidelines like ARRIVE to write a manuscript which adequately describes the study
  3. Make sure that any advances in the 3Rs which were made during the study are prominently mentioned in the manuscript, preferably in the title and/or abstract, since many databases only index these parts of a paper.

PREPARE includes topics which may not be necessary to report in a scientific paper, but which can seriously affect the scientific validity of an animal study, its reproducibility and its translatability, and animal welfare. In addition PREPARE addresses the potential health risks to both humans and animals, and gives advice on how to ensure a Culture of Care.

Also, the PREPARE checklist is just the top of an iceberg: all the topics in PREPARE are discussed in more detail, with many links to international resources, under the headings on the main PREPARE page.

Click on the picture to see a 3-minute film about the roles of planning and reporting guidelines.

PREPARE film storyboard

Further reading

This page was updated on 21 August 2020

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