Relationship between PREPARE and ARRIVE
The PREPARE guidelines for planning animal experiments are complementary to reporting guidelines such as ARRIVE. They should be used in conjunction, to ensure that important topics have not been omitted. PREPARE includes topics which are not necessary to report in a scientific paper, but which can seriously affect the scientific quality of an animal study (as well as causing health risks to both humans and animals) if they are not addressed satisfactorily.
Formulation of the study
1. Literature searches
2. Legal issues
3. Ethical issues, Harm-Benefit Assessment and humane endpoints
4. Experimental design and statistical analysis
Dialogue between scientists and the animal facility
5. Objectives and timescale, funding and division of labour
6. Facility evaluation
7. Education and training
8. Health risks, waste disposal and decontamination
Quality control of the components in the study
9. Test substances and procedures
10. Experimental animals
11. Quarantine and health monitoring
12. Housing and husbandry
13. Experimental procedures
14. Humane killing, release, re-use or re-homing
5. Ethical statement
6. Study design
7. Experimental procedures
8. Experimental animals
9. Housing and husbandry
10. Sample size
11. Allocating animals to experimental groups
12. Experimental outcomes
13. Statistical methods
14. Baseline data
15. Numbers analysed
16. Outcomes and estimation
17. Adverse events
18. Interpretation/scientific implications
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