This section will be used to publish resources for fish researchers and animal care staff.
The RSPCA arranged a meeting on 23 February 2021 entitled Focus on Fish, which contained several relevant presentations. There was a session on Welfare Assessment and Humane Endpoints, including identifying ill health in zebrafish; humane endpoints and the 3Rs in regulatory assessments; and refining the Fish Acute Toxicity Test (OECD TG203).
Adam Staszny et al. (2021), working on fish ecotoxicity, have shown that the output of traditional risk assessment based on ecotoxicological data is not necessarily consistent with the real-life situation, and that changes in body and fin shape may good sub-lethal endpoints when performing in vivo studies.
- Andersen et al. (2023): Defining piscine endpoints: Towards score sheets for assessment of clinical signs in fish research
- Heather Ikert et al. (2021) have investigated the possible use of circulating plasma microRNAs as biomarkers for the identification of acute stress responses in fish.
- Video-based identification of surrogate endpoints in experimental bacterial infections of rainbow trout (Oncorhynchus mykiss) (Keeling, 2018, Doctoral Thesis).
- Ellis and Katsiadaki (2020) Clarification of early end-points for refinement of animal experiments, with specific reference to fish. Laboratory Animals, 55(3): 244-253.