Necropsies should be planned with the same systematic attention to detail as that required by the in vivo study, to avoid bias or loss of material during the procedure or in storage afterwards. An SOP should be followed for all animals, even in the absence of macroscopic lesions. Necropsy findings unrelated to the study but of potential concern to the facility, breeder or supplier should be reported to the relevant parties. All carcasses should be labelled individually, so that they can be identified even after the routine necropsy has been performed, in case it proves necessary to take more samples, or necropsy more animals, than originally intended.
Diagnostic necropsy and selected tissue and sample collection in rats and mice (JOVE video)
Development of a necropsy protocol for newborn mice (Sara Capas Paneda et al., Porto)
A simplified necropsy technique for mice: making the most out of unscheduled deaths (Scudamore et al., 2014)
Tissue Sampling and Processing for Histopathology Evaluation (Slaoui et al., 2017)
Links to more guidance on necropsies are available here.
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